Igor Dawid

Making a tubule the noncanonical way.

Dishevelled and Wnt signaling: is the nucleus the final frontier?

The phosphoprotein Dishevelled (Dsh) is an essential component of Wnt signaling pathways and transduces signals into three separate branches, the canonical, non-canonical and Ca2+ pathways. How Dsh focuses signaling into these branches remains mysterious, but a new study reveals the importance of nuclear localization of Dsh for pathway-specific activation.

Organizing the Vertebrate Embryo—A Balance of Induction and Competence

In what is usually referred to as the most famous experiment in embryology, Hans Spemann and Hilde Mangold (1924) showed that a specifi c region in early frog embryos called the blastopore lip can induce a second complete embryonic axis, including the head, when transplanted to a host embryo. Most of the axis, including the nervous system, was derived from the host, whose cells were induced to ...

Zebrafish GADD45 genes are involved in somite segmentation

*Laboratory of Developmental Molecular Genetics, Horizontal Medical Research Organization, Kyoto University Faculty of Medicine, Yoshida, Sakyo-Ku, Kyoto 606-8501, Japan; §Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan; and †Laboratory of Molecular Genetics, National Institute of Child Health and Human Developmen...

Expression of the Krüppel-like zinc finger gene biklf during zebrafish development

The zebrafish biklf gene encodes a novel Krüppel-like transcription factor containing three contiguous zinc fingers at the C-terminus. Expression of biklf is detected from the shield stage onward in the developing prechordal plate, and as a 'baseball seam'-like lateral stripe beginning at the end of gastrulation. The latter expression domain is suppressed in the swirl mutant in which bmp2b is d...